Corporation Xenotox (Part 1) - an endpoint of the route from Xenobiochemistry (Part 2) through Dioxin Research (Part 3) to Xenovirology (Part 4).

1. Xenotox, Inc.

New York Corporation (Incorporated 08/29/2005)

New York S Corporation (since 2013)

Tax ID: 203535033

Xenotox Inc.pdf
XENOTOX, Inc. provides innovation and consulting services to the life sciences academia and industry. It focuses on two science/biotech research areas both originated from previous discoveries:

Concept of Xenobiotical Virology.

(For more details please see Part 4 on this Website).

Development of New Long-Acting Medicines by Site-Directed Modification of Drug Structure.

(The content of this subject is truncated due to patenting process requirements).

Wikipedia article about Ilya B. Tsyrlov, a President/CSO at Xenotox, Inc.

1. Notable Contributions to Applied Clinical Research:
• Modeling of Human Laennec’ Type of Cirrhosis. (details in Part 2.2.1.).
        Tsyrlov, I.B., Mishin, V.M., Lyakhovich, V.V. (November 1972). “Resistance of microsomes from CCl4-cirrhotic rat liver to lipoperoxidation activity”. Life Sciences 11(21):1045-1054. DOI: 10.1016/0024-3205(72)90206-8;
        Mishin, V., Tsyrlov, I., Gromova, O., Lyakhovich, V. (May 1974). “Phospholipids as cinchocaine action site during inhibition of lipoperoxidative reactions in rat liver microsomes”. Hoppe-Seyler’s Zeitschrift fur Physiologische Chemie. 355:626-632. ISSN: 0372-9672;
        Tsyrlov, I.B., Lyakhovich, V.V. (May 1975). “Rate-limiting steps in drug metabolism by microsomes from CCl4-cirrhotic rat liver”. Chemico-Biological Interactions 10:77-89. DOI: 10.1016/0009-2797(75)90102-7.
• Effects of Primary and Secondary Bile Acids on Hepatic CYPs During Cholestasis Development. (details in Part 2.2.3.).
        Tsyrlov, I.B., Zakharova-Polyakova, N.E., Gromova, O.A., Pospelova, L.N., Lyakhovich, V.V. (October 1978). “An in vivo – in vitro comparison of the effects of bile acids on the structural organization and functional activity of liver microsomal monooxygenases”. Experimental and Molecular Pathology. 20:131-143. DOI:10.1016/0014-4800(78)90033-3
        Lyachovich, V.V., Tsyrlov, I.B. ”Structural Aspects of Monooxygenases Biochemistry” (“Структурные Аспекты Биохимии Монооксигеназ»)  (July 1978). Novosibirsk, Nauka Publishing House. Ed. Academician Rudolf  Salganik. 242 pp. ISBN:21003-743/686-78               
        Tsyrlov, I.B., Polyakova, N.E., Gromova, O.A. Rivkind, N.B., Lyakhochovih, V.V. (March 1979). “Cholestasis as an in vivo model for analysis of the induction of liver microsomal monooxygenases by sodium phenobarbital and 3-methylcholanthrene”. Biochemical Pharmacology 28:1473-1478. DOI: 10.1016/0006-2952(79)90460-X         
• Understanding the Mechanisms of PAH-Dependent Tumorigenesis and Dioxin-Triggered Viral Carcinogenesis. (details in Part 3.1.2.).
        Tsyrlov, I.B., Duzchak, T.G. (November 1990). “Interspecies features of hepatic cytochromes P450 IA1 and P450 IA2 in rodents”. Xenobiotica 20(11):1163-1170. DOI:10.3109/00498259009046836
        Tsyrlov, I.B., Lyakhovich, V.V. (April 1979). “A comparison of the activities of aryl hydrocarbon monooxygenase in liver microsomes from mice of different strains during prolong 3,4-benzo(a)pyrene administration”. Biochimica et Biophysica Acta 584:11-20. ISSN: 0304-4165
        Lyakhovich, V.V., Tsyrlov, I.B. (February 1981). “Индукция Ферментов Метаболизма Ксенобиотиков” (in Russian). “Induction of Xenobiotic Metabolizing Enzymes”. 239 pp. Ed. Academician A. Yasaitis. Novosibirsk, Nauka Publishing House. ISBN: MH-05082
        Goldman, R., Tsyrlov, I.B., Grogan, J., Kagan, V.E. (March 1997). “Reaction of phenoxyl radicals with NADPH-cytochrome P-450 oxidoreductase and NADPH: reduction of the radicals and inhibition of the enzyme”. Biochemistry 36:3186-3192. DOI: 10.1021/bi9621728               
        Tsyrlov, I.B., Pokrovsky, A.G., Wu, J., Shur, I.N. (September 2015). “Multidisciplinary approach to the trans-activation of human Hepatitis B Virus by body burden dioxin or dioxin-like polychlorinated biphenyls”. Journal of Viral Hepatitis 22 (S3-P40):27-28. Online ISSN:1365-2893        
• Revealing CYP1A2 as the Major Alcohol-Metabolizing Monooxygenase in Human Liver. (details in Part 2.4.3.).
        Tsyrlov, I.B., Goldfarb, I.S., Gelboin, H.V. (December 1993). “Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2”. Archives of Biochemistry and Biophysics 307:259-266. DOI:10.1006/abbi.1993.1588
        Salmela, K.S., Kessova, I.G, Tsyrlov, I.B., Lieber, C.S. (December 1998). “Respective roles of human cytochrome P4502E1, 1A2 and 3A4 in the hepatic microsomal ethanol oxidizing system”. Alcoholism: Clinical and Experimental Research 22:2125-2132. DOI: 10.1111/j.1530-0277.1998.tb05926.x
        Chaloupka, K., Santostefano, M., Goldfarb, I.S., Liu, G., Myers, M.J., Tsyrlov, I.B., Gelboin, H.V., Krishnan, V., Safe, S. (December 1994). “Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice”. Carcinogenesis 15:2835-2840. DOI:10.1093/carcin/15.12.2835
• Dioxin-Activated Herpes Viruses Linked to Inflammatory Pathways in Human Cells. (details in Part 4.5.1.-4.5.3.).
        Tsyrlov, I.B., Shur, I.N., Oshchepkov, D.Yu., Pokrovsky, A.G. (June 2012). "Xenobiotical virology: novel mechanistic concept of hazardous human viruses upregulation by body burden level of dioxins via AhR-mediated transcriptional pathway". International Journal of Infectious Diseases. 16(S1):e115-119. DOI:org/10.1016/j.ijid.2012.05.258.e112
        Wu, J., Shur, I.N., Tsyrlov, I.B. (July 2008). “Current human body burden of dioxins might upregulate DRE-containing cytomegalovirus (CMV) linked to inflammation and malignancy pathways”. Organohalogen Compounds 70: 1471-1474 (2008). ISSN:1026-4892
        Tsyrlov, I.B., Shur, I.N., Wu, J., Furman, D.N., Oshchepkov, D.Yu. (August 2014). A proposed mechanism of transactivation by body burden dioxin of Herpes Simplex Virus genes might be responsible for weakening the host antiviral defense”. Organohalogen Compounds 76:289-292. ISSN:1026-4892
• Prolonged-Release Dosage Forms of First-Line Analgesics, Synthetic Opioids, and Antimalarials. (details in Part 2.3.3.).
        Tsyrlov, I.B., Gerasimov, K.G. (May 1986). “New Approach to Production of Prolong Acting Medicines Facilitating  Hepatic Drug Detoxification System“. Patent SU/EP: 1457593 A1 4 G 01 N 33/48
        Tsyrlov, I.B., Gerasimov, K.G. (June 1991). “Aminopyrine-N-demethylase I. Directed modification of substrates' structure as a way of production of inducer of the monooxygenase isoform P-450b”. European Journal of Drug Metabolism and Pharmacokinetics 16(3):207-212. DOI:10.1007/BF03189961
        Tsyrlov, I.B., Woo, C.S.T., Martin, V.P., Shur, I.N. (April 2014). “Modification of CYP2B6-mediated site of metabolism on Artemisinin molecule as a way to prolong its maximal antimalarial efficacy”. International Journal of Infectious diseases 21(S1):174-177. DOI:10.1016/j.ijid.2014.03.784
• Mouse Model of Human Clonal Hematopoiesis of Indeterminate Potential (CHIP) (details in Part 3.1.3.).
        Tsyrlova, I.G., Kozlov, V.A., Tsyrlov, I.B. (April 1986). “A new experimental model for studying bone marrow cells participation in antibody genesis”. Cytology 28:102-106. UDC:57.083.3:612.419
2. Notable Contributions to Basic Biomedical Research:
• Revealing of "Substrate-Type" Induction Mechanism for CYP2B Enzymes by Phenobarbital-like Xenobiotics (details in Part 2.3.2.).
        Tsyrlov, I.B., Zakharova, N.E., Gromova, O.A., Lyakhovich, V.V. (January 1976). “Possible mechanism of induction of liver microsomal monooxygenase by phenobarbital”. Biochimica et Biophysica Acta 421:44-56. DOI: 10.1016/0304-4165(76)90168-9
        Tsyrlov, I.B., Polyakova, N.E., Gromova, O.A. Rivkind, N.B., Lyakhovich, V.V. (March 1979). “Cholestasis as an in vivo model for analysis of the induction of liver microsomal monooxygenases by sodium phenobarbital and 3-methylcholanthrene”. Biochemical Pharmacology 28:1473-1478. DOI: 10.1016/0006-2952(79)90460-X
        Lyakhovich, V.V., Tsyrlov, I.B. (February 1981). “Индукция Ферментов Метаболизма Ксенобиотиков” (in Russian). “Induction of Xenobiotic Metabolizing Enzymes”. 239 pp. Ed. Academician A. Yasaitis. Novosibirsk, Nauka Publishing House. ISBN: MH-05082
• “Mutual Depletion Inhibition System” for Quantification of CYP Active Centers (details in Part 2.4.1.)
        Tsyrlov, I.B., Lyakhovich, V.V. (September 1978). "Genetic variations in cytochrome P-450 (P-448) catalytic center activities in relation to subsequent conjugation reactions". In: Conjugation Reactions in Drug Biotransformation, Ed. A. Aitio, Elsevier/North-Holland Biomedical Press, Amsterdam-New York, Oxford. pp.135-145. ISBN:0-444-80090-5
        Anshitz, A.G., Sokolovsky, V.D., Burilin, S.Yu., Lyakhovich, V.V., Tsyrlov, I.B. (January 1979). “Influence of inducer structure on catalytic activities of microsomal enzymes”. Kinetics and Catalysis (Science Press) 20(4):865-869. UDK: 577.15.02:577.158
        Lyakhovich, V.V., Tsyrlov, I.B. (February 1981). “Индукция Ферментов Метаболизма Ксенобиотиков” (in Russian). “Induction of Xenobiotic Metabolizing Enzymes”. 239 pp. Ed. Academician A. Yasaitis. Novosibirsk, Nauka Publishing House. ISBN: MH-05082
• Comparative Enzyme-Kinetics of cDNA-expressed, Purified and Microsomal CYPs (details in Parts 2.4.1.; 2.4.2. & 3.1.2.).
        Lyachovich, V.V., Tsyrlov, I.B. ”Structural Aspects of Monooxygenases Biochemistry” (“Структурные Аспекты Биохимии Монооксигеназ»)  (July 1978). Novosibirsk, Nauka Publishing House. Ed. Academician Rudolf  Salganik. 242 pp. ISBN:21003-743/686-78
        Tsyrlov, I.B., Duzchak, T.G. (November 1990). “Interspecies features of hepatic cytochromes P450 IA1 and P450 IA2 in rodents”. Xenobiotica 20(11):1163-1170. DOI:10.3109/00498259009046836
        Tsyrlov, I.B., Lyakhovich, V.V. (April 1979). “A comparison of the activities of aryl hydrocarbon monooxygenase in liver microsomes from mice of different strains during prolong 3,4-benzo(a)pyrene administration”. Biochimica et Biophysica Acta 584:11-20. ISSN: 0304-4165
        Lyakhovich, V.V., Tsyrlov, I.B. (February 1981). “Индукция Ферментов Метаболизма Ксенобиотиков” (in Russian). “Induction of Xenobiotic Metabolizing Enzymes”. 239 pp. Ed. Academician A. Yasaitis. Novosibirsk, Nauka Publishing House. ISBN: MH-05082
        Tsyrlov, I.B., Goldfarb, I.S., Gelboin, H.V. (December 1993). “Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2”. Archives of Biochemistry and Biophysics 307:259-266. DOI:10.1006/abbi.1993.1588
        Tsyrlov, I.B., Mikhailenko, V.M., Gelboin, H.V. (March 1994). “Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids”. Biochimica et Biophysica Acta 1205:325-335. DOI: 10.1016/0167-4838(94)90252-6
        Goldman, R., Tsyrlov, I.B., Grogan, J., Kagan, V.E. (March 1997). “Reaction of phenoxyl radicals with NADPH-cytochrome P-450 oxidoreductase and NADPH: reduction of the radicals and inhibition of the enzyme”. Biochemistry 36:3186-3192. DOI: 10.1021/bi9621728
        Sinclair, P.R., Gorman, N., Tsyrlov, I.B., Fuhr, U., Walton, H.S., Sinclair, J.F (October 1998). “Uroporphyrinogen oxidation catalyzed by human cytochromes P450”. Drug Metabolism and Disposition 26:1019-1025. Print ISSN: 0090-9556. PubMed: 9763408A
        Salmela, K.S., Kessova, I.G, Tsyrlov, I.B., Lieber, C.S. (December 1998). “Respective roles of human cytochrome P4502E1, 1A2 and 3A4 in the hepatic microsomal ethanol oxidizing system”. Alcoholism: Clinical and Experimental Research 22:2125-2132. DOI: 10.1111/j.1530-0277.1998.tb05926.x
        Chaloupka, K., Santostefano, M., Goldfarb, I.S., Liu, G., Myers, M.J., Tsyrlov, I.B., Gelboin, H.V., Krishnan, V., Safe, S. (December 1994). “Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice”. Carcinogenesis 15:2835-2840. DOI:10.1093/carcin/15.12.2835
• Protonophores Used to Uncover Different Hydrophobic Zones in Microsome Membrane Specific for CYP (details in Part 2.2.2.].
        Tsyrlov, I.B., Gromova, O.A., Lyakhovich, V.V. (October 1976). “Mechanism of inhibition by carbonyl cyanide m-chlorophenylhydrozone and sodium deoxycholate of cytochrome P-450-catalyzed hepatic microsomal drug metabolism”. The Biochemical Journal. 160(1):75-83. DOI:10.1042/bj1600075
• A Koshland-Type Conformational Plasticity of CYP Active Center Determining Inducer-Driven Substrate Specificity (details in Part 2.3.2.).
        Anshitz, A.G., Sokolovsky, V.D., Burilin, S.Yu., Lyakhovich, V.V., Tsyrlov, I.B. (January 1979). “Influence of inducer structure on catalytic activities of microsomal enzymes”. Kinetics and Catalysis (Science Press) 20(4):865-869. UDK: 577.15.02:577.158
        Tsyrlov, I.B., Gerasimov, K.G. (June 1991). “Aminopyrine-N-demethylase I. Directed modification of substrates' structure as a way of production of inducer of the monooxygenase isoform P-450b”. European Journal of Drug Metabolism and Pharmacokinetics 16(3):207-212. DOI:10.1007/BF03189961
        Tsyrlov, I.B., Woo, C.S.T., Martin, V.P., Shur, I.N. (April 2014). “Modification of CYP2B6-mediated site of metabolism on Artemisinin molecule as a way to prolong its maximal antimalarial efficacy”. International Journal of Infectious diseases 21(S1):174-177. DOI:10.1016/j.ijid.2014.03.784
• Triggering Effects of 2,3,7,8-TCDD on HIV-1, CMV, HSV-1, HBV and NS1BP genes expression in Human Target Cells (details in Parts 3.4.1.-3.4.3. & 3.5.)
        Pokrovsky, A.G., Chernykh, A.I., Yastrebova, O.N., Tsyrlov, I.B. (August 1991). “2,3,7,8-tetrachlorodibenzo-p-dioxin as a possible activator of HIV infection”. Biochemical and Biophysical Research Communications 179:46-51. ISSN: 0006-291X
        Tsyrlov, I.B., Pokrovsky, A.G. (September 1993), “Stimulatory effect of the CYP1A1 inducer 2,3,7,8-tetrachlorodibenzo-p-dioxin on the reproduction of HIV-1 in human lymphoid cell culture”. Xenobiotica 23:457-467. DOI: 10.3109/00498259309057034
        Tsyrlov, I.B. (July 2006). “The role of body burden 2,3,7,8-TCDD in triggering malignancy-associated human viruses: from early data to mechanistic concept”. Organohalogen Compounds 68:552-555. ISSN:1026-4892
        Tsyrlov, I.B., Shur, I.N. (August 2008). "Mechanistic Insight into Activation by Dioxin-Type Xenobiotics of Cancer-Linked Common Human Viruses and HIV-1 Virus". The Lancet Infectious Diseases 8:P496-9. DOI:10.1016/70172-5
        Tsyrlov, I.B., Pokrovsky, A.G., Wu, J., Shur, I.N. (September 2015). “Multidisciplinary approach to the trans-activation of human Hepatitis B Virus by body burden dioxin or dioxin-like polychlorinated biphenyls”. Journal of Viral Hepatitis 22 (S3-P40):27-28. Online ISSN:1365-2893
        Wu, J., Pokrovsky, A.G., Rumak, V.S., Tsyrlov, I.B. (July 2007). “Regulation of human gene of Influenza A virus-associated NS1-binding protein by 2,3,7,8-TCDD: mechanistic data and epidemiological findings”. Organohalogen Compounds 69(2):1885-1889. ISSN:1026-4892
        Tsyrlov, I.B., Shur, I.N., Roumak, V.S. (August 2017). “The NS1A binding protein in alveolar epithelial cells as centerpiece of Influenza virus A lung injury mechanism mediated via AhR/Arnt signaling pathway”. European Respiratory Journal 50:PA352. DOI:10.1183/1393003.congress-2017.PA352
• Revelation of Potentially Active Promoter DREs in Human Dormant Viruses, and Mammalian Genes Encoding Cytosolic Ah Receptor Complex Components (details in Part 3.2.).
        Lyakhovich, V.V., Tsyrlov, I.B. (February 1981). “Индукция Ферментов Метаболизма Ксенобиотиков” (in Russian). “Induction of Xenobiotic Metabolizing Enzymes”. 239 pp. Ed. Academician A. Yasaitis. Novosibirsk, Nauka Publishing House. ISBN: MH-05082
        Tsyrlov, I.B., Shur, I.N., Oshchepkov, D.Yu., Pokrovsky, A.G. (June 2012). "Xenobiotical virology: novel mechanistic concept of hazardous human viruses upregulation by body burden level of dioxins via AhR-mediated transcriptional pathway". International Journal of Infectious Diseases. 16(Suppl. 1):e115-119. DOI:org/10.1016/j.ijid.2012.05.258.e112
        Wu, J., Shur, I.N., Tsyrlov, I.B. (July 2008). “Current human body burden of dioxins might upregulate DRE-containing cytomegalovirus (CMV) linked to inflammation and malignancy pathways”. Organohalogen Compounds 70: 1471-1474 (2008). ISSN:1026-4892
        Tsyrlov, I.B., Shur, I.N., Wu, J., Furman, D.N., Oshchepkov, D.Yu. (August 2014). A proposed mechanism of transactivation by body burden dioxin of Herpes Simplex Virus genes might be responsible for weakening the host antiviral defense”. Organohalogen Compounds 76:289-292. ISSN:1026-4892
• Inception of Xenobiotical Virology as Interdisciplinary Field linked to Inflammatory and Neurodegenerative Diseases (details in Part 4.2.1.-4.2.3.; 4.3.1.; 4.5.1-4.5.3.].
        Tsyrlov, I.B., Shur, I.N., Oshchepkov, D.Yu., Pokrovsky, A.G. (June 2012). "Xenobiotical virology: novel mechanistic concept of hazardous human viruses upregulation by body burden level of dioxins via AhR-mediated transcriptional pathway". International Journal of Infectious Diseases. 16(S1):e115-119. DOI:org/10.1016/j.ijid.2012.05.258.e112
        Tsyrlov, I.B., Shur, I.N., Wu, J., Furman, D.N., Oshchepkov, D.Yu. (August 2014). A proposed mechanism of transactivation by body burden dioxin of Herpes Simplex Virus genes might be responsible for weakening the host antiviral defense”. Organohalogen Compounds 76:289-292. ISSN:1026-4892
        Tsyrlov, I.B., Wu, J., Shur, I.N., Oshchepkov, D.Yu. (July 2016). “Alzheimer’s disease causative viruses HSV-1 and CMV are highly susceptible targets for bHLH/PAS dioxin receptor-Arnt transcription pathway in glial cells”. Alzheimer's and Dementia. The Journal of the Alzheimer Association 12(7):P632-635. DOI:10.1016/j.jalz.2017.06.2252
        Tsyrlov, I.B., Shur, I.N., Appelbaum, J., Wu, J. (June 2017). “AhR-ARNT signaling pathway mediates transcriptional activation of HSV-1 in glial cells: a pathogenic factor that might affect AD development”. Alzheimer's and Dementia. The Journal of the Alzheimer Association 13(7):P1438-P1439. DOI: 10.1016/j.jalz.2017.06.2252

Education and Scientific Occupation

Ilya Tsyrlov attended Novosibirsk Medical University, Russian Federation (1964-1970) graduating with M.D. degree (with distinction) in Internal Medicine, Diploma No. P467542 (1970).

In 1973, he got a Ph.D. degree in Biochemistry, Thesis: "Structural and Functional Changes of Biological Oxidation Systems During Liver Cirrhosis Development". Scientific Supervisor: Prof. Vyacheslav Lyakhovich. Official Opponents: Prof. Rudolf Salganik, Prof. Yu. Izumov.

11F62B8F-6C65-4042-BE51-E8D0C76E6601_1_105_c
First Plenary lecture at International Conference in Turku, Finland (1978)

In 1983, Tsyrlov earned a higher doctorate degree of D.Sc. degree (Doctor of Biological Sciences, Specialty: Biochemistry) from Institute of Experimental Medicine, Russian Academy of Sciences. Thesis: "INDUCTION BY XENOBIOTICS, AND FUNCTIONAL PROPERTIES OF MEMBRANE-BOUND MONOOXYGENASES". Official Opponents: Academician R. Salganik, Prof. A. Archakov, Prof. V. Gaitzhoki.

For 20 years Tsyrlov held progressively responsible positions of Research Team Leader (1972-79), and Head of Laboratory of Xenobiochemistry (1979-92), at Institute of Experimental and Clinical Medicine (since 1998 - Institute of Molecular Biology and Biophysics http://www.imbb.soramn.ru/ , Russian Academy of Sciences.

Below are pictures of Dr. Tsyrlov' fellow colleagues throughout his term as a scientist in the former Soviet Union:

founding four machos, the late 1960s
The early-1970s. "The Captain and Three Musketeers": V. Lyakhovich, A. Panov, V. Mishin, I. Tsyrlov.

1970s
The early-1980s: V. Lyakhovich, V. Mishin, A. Panov, V. Ostashevsky, O. Khatsenko, V. Solovjev (late), K. Gerasimov, D. Maletin.

IMG-4290
The mid-1980s: A. Grishanova, V. Mishin, D. Mishina, V. Vavilin, L. Vavilina, O. Gromova, A. Panov, N. Gutkina, S. Makarova, A. Chasovnikov, L. Gulyaeva, O. Kondrashova-Chasovnikova, I. Balzovskaya.

1980s
The late-1980s: Yu. Levin, N. Gutkina, K. Gerasimov, N. Kozlovskaya, V. Ostashevsky, A. Grishanova.

1990s
The mid-1990s: N. Slinko, O. Chasovnikova, T. Subhankulova, I. Tsyrlov (visited from USA), S. Kovalenko, V. Vavilin, A. Grishanova, I. Kessova, N. Polyakova, A. Panov (visited from USA), unknown person, L. Gulyaeva.

2000s
The mid-2000s: I. Tsyrlov (visited from USA), L. Gulyaeva, V. Lyakhovich.

In 1990, the US National Institutes of Health (NIH) designated Tsyrlov as "internationally recognized scientist with a distinguished record of accomplishment", and hired him as a Senior Enzymologist at a renowned Laboratory of Molecular Carcinogenesis (headed by Harry Gelboin), National Cancer Institute/NIH, where Tsyrlov worked till 1995. Thereafter, he held positions of Research Associate Professor/Professor/Visiting Professor at the Department of Medicine and the Division of Occupational and Environmental Medicine, Mount Sinai School of Medicine (since 1996 - Icahn School of Medicine at Mount Sinai), New York, NY. In 2005, Tsyrlov founded the Xenotox, Inc., a life sciences consulting company certified with New York State, where he served a Chief Scientific Officer. In 2009, Tsyrlov became the company's President/CSO. The Xenotox, Inc. is implementing an earlier discovered site-directed synthesis of long-acting medications, and thoroughly studying the transactivation of the human herpesviruses by bodily dioxin in the picomolar range.

Recognitions and honors

Tsyrlov was endorsed by the governmental agency, the Higher Attestation Commission of the Ministry of Education and Science, awarding him title of a “Senior Research Scientist” (certificate #CH 18029, 1980), thereafter elevated to a distinguished level quoted for Doctors of Sciences (certificate BL 0011240, 1983).

DSci
RAS Academician Abel Aganbegyan handed over a Doctor of Sciences Diploma (autumn of 1983).

Tsyrlov had participated in the organizing drug metabolism scientists from 45 countries into International Society for Study of Xenobiotics, ISSX (www.issx.org), which currently is one of the largest research societies worldwide, and has served a Regional Editor of ISSX Newsletter (1981-90), a member of the International Scientific Affairs Committee (1992-99) and Nominating Committee (1991-97). In 2015, the ISSX Council elected Tsyrlov its Emeritus Member/Fellow.

IMG_0922
With ISSX founder Academician Ron Estabrook and Prof. Fred Guengerich at the Xenobiochemistry Congress in Bratislava (1980).


Editorship at the ISSX journal (back cover)

In 1989, Tsyrlov got a special invitation from Robert Wood Johnson Medical School, The Environmental and Occupational Health Sciences Institute to deliver the Rutgers Distinguished "First Special Lecture of the International Program", entitled "Biological & Medical Aspects of Polychlorinated Dioxins".

In 1992, Tsyrlov was granted by US government the Alien of Extraordinary Ability category reserved for distinguished foreign national professionals.

In 1992, Tsyrlov was selected by the World Health Organization WHO Council to final candidate for the post of Director of the International Agency for Research on Cancer (IARC).

WHO/IARC

In 2006, Tsyrlov was invited by US EPA's Distinguished Lecture Series to deliver a seminar on "The Role of Body Burden 2,3,7,8-TCDD in Triggering Malignancy-Associated Human Viruses: From Early Data to Mechanistic Concept".

2006 EPA Lecture July252006 (5).pdf

In the 1980s-2000s, he has been invited to deliver special lectures and seminars at universities of 14 countries, research companies (Hoechst AG, Frankfurt, Merck Sharp/Rahway, Boehringer Ingelheim/Ridgefield, etc.) and governmental agencies (NIH, EPA, DHHS, CDC, Cancer Research UK). Tsyrlov has served a member of Organizing Committee of International meeting DIOXIN'1985, Germany; International ISSX Meeting'1995, USA; DIOXIN meeting'2006, Norway; Alzheimer's Association International Conference'2016, Canada; Influenza Congress'2017, UK; Infectious Diseases Congress'2018, Japan; etc. He was (together with Vyacheslav Lyakhovich) an Editor of “Cytochrome P450 and Environment” book (1987), and edited several congressional proceedings on drug metabolism and various aspects of hazard xenobiotics. He served a Session Chair/Plenary lecturer at eleven national/international meetings, and a Keynote Speaker at nine national/international congresses. Since the 1990s, Tsyrlov has been a senior reviewer of the International Human Frontier Science Program. Also, he served an officer/fellow of European Society of Biochemical Pharmacology, Liver Diseases and Hepatitis Program, ASBMB, American Cancer Society, Society of Environmental Toxicology and Chemistry, The Biochemical Society, AAAS, SOT, FAS, and Alzheimer Research Forum.

An open-minded public speaker, Tsyrlov has exposed environmental issues of hazard xenobiotics that affect human health. He addressed environmental health problems that existed throughout the Soviet Union/Russia (“The Ailing Mother Russia”. ''Environmental Health Perspectives'' 102, #2, Feb 1994 1994 paper in EHP .pdf. The same year Tsyrlov was invited as a distinguished member to US CDC and Citizen Ambassador Program' delegation to attend a conference with the Russian Ministry of Environmental Protection, held in Moscow. With the President of Fishkill Ridge Caretakers, Inc., Peter Rostenberg, MD, Tsyrlov petitioned on behalf of the Superfund Research Program to then Governor of New York State George Pataki to support clean up of the toxic polychlorinated biphenyls deposited over 30 years by the General Electric Corporation in the Hudson River (“GE wants to stick to own PCB control” and other articles in the ''Poughkeepsie Journal'' (2000-02).

In 2006, Tsyrlov was specially invited to co-chair the International Scientific Conference “Victims of Agent Orange/Dioxin in Vietnam – the Expectation” in Vietnam, where he made two keynote scientific communications on damaging effects of dioxin-like compounds (DLC). Tsyrlov chaired meetings of American and Vietnamese widows commemorating Vietnam War fallen warriors, for that the Vietnamese government bestowed him with Ly-Viet Hands antique. In 2005-07, Tsyrlov consulted the US government in international issues on dioxins toxicity and was awarded by US Vice President Richard Cheney.

Tsyrlov has published 6 books,

10 reviews and book chapters, and 260+ peer-reviewed papers in world's academic research journals with the SNIP of 4.0 and higher, such as Archives of Biochemistry and Biophysics; Biochemistry; The Biochemical Journal; Carcinogenesis; Chemosphere; Drug Metabolism and Disposition; Chemico-Biological Interactions; FEBS Letters; Experimental and Molecular Pathology; Hoppe-Seyler's Zeitschrift für Physiologische Chemie; Journal of Viral hepatitis; Lancet Infectious Diseases; Alcoholism: Clinical and Experimental Research; Life Sciences; International Journal of Infectious Diseases; Environmental Health Perspectives; Alzheimer’s and Dementia (The Journal of the Alzheimer’s Association); Virology Research Journal; European Respiratory Journal; Drug Metabolism Reviews. By author-level scientometrics analysis, Tsyrlov's i6-index is 28, and his published results have been full-text read/downloaded by 56,000+ scientists worldwide (https://www.researchgate.net/profile/Ilya_Tsyrlov).

Publications

Books:
        • Ilya Tsyrlov: "POLYCHLORINATED DIOXINS: BIOLOGICAL AND MEDICAL ASPECTS". The National Academy of Sciences, 1990, 239 pp. + illustrations edited by Academician V. Vlassov, 01/1990; NAUKA Publishing House, ISBN: BBK P 284.6 50300-887-1990
        • Vyacheslav Lyakhovich and Ilya Tsyrlov (editors) "CYTOCHROME P-450 AND ENVIRONMENT". 1987, 411 pp. National Academy of Sciences Publishing House.
        • Ilya Tsyrlov and Vyacheslav Lyakhovich: Genetic Variations in Cytochrome P-450(P-448) Catalytic Centers Activities in Relation to Subsequent Conjugation Reactions. CONJUGATION REACTIONS IN DRUG BIOTRANSFORMATION, Amsterdam-New York-Oxford. Edited by A. Aitio, 01/1978: Elsevier/North-Holland Biomedical Press., ISBN: 0-444-80090-5
        • Vyacheslav Lyakhovich and Ilya Tsyrlov: "INDUCTION OF XENOBIOTICS METABOLIZING ENZYMES". National Academy of Science, Edited by Academician A. Yasaitis, 1981; Science Press, 341 pp.., ISBN: 50300-737 18-14-1980
        • Vyacheslav  Lyakhovich and Ilya B. Tsyrlov: "STRUCTURAL ASPECTS OF MONOOXYGENASES BIOCHEMISTRY", Edited by Academician R. Salganik, 1978; 337 pp., "Science Press",  ISBN: 21003-743 686-78
        • Ilya Tsyrlov: Factors Controlling Induction of Different Forms of P-450 in the Liver. MOLECULAR MECHANISMS OF CELLULAR HOMEOSTASIS, National Academy of Science. Edited by Academician I. Gitelzon, 01/1987; NAUKA Publishing House., ISBN: 50303-747 18-14-1987
Book Chapters:
        • Ilya Tsyrlov, Vladimir Ostashevsky, K. Gerasimov, V. Rumak: Characteristics of Hepatic and Lymphocyte Monooxygenases in South Vietnam' People with Chlorophenoxy Herbicides Exposure. IARC monographs on the evaluation of carcinogenic risks to humans. Volume 113., Supplement 06/2015; volume 113 06/2015; World Health Organization, International Agency for Research on Cancer, WHO.
        • Ilya Tsyrlov, Vladimir Ostashevsky: 389:;<= <8>?@9@<=ABC@D@ @>89A;C8E >9;C@F8@:8>@G G A8<H@I8:=J \>?@G8 K8:;A;L .B;:C=<=, M@NG;?D=GO8J9E G@PN;L9:G8Q N8@>98C@G. «0*123*45 – 36789123*0:4;5 21-<& "82:», Russian National Acfdemy of Science, Institute of Evolution after Severtsev edited by G. Sofronov, V. Rumak, 09/2006: chapter 3(=>?@A @(B.&=&@A/CD&<& &B(=/?D($ B=?D&E(&>(B&' ' /(@F&G(>A% B.&'( H(>?/?I "C?>DA@A, J&K'?.<A'L(%=$ '&MK?I=>'(N K(&B=(D&': pages 77-95; NAUKA/Elsevier Interperiodica.
        • Ilya Tsyrlov: DIOXIN-LIKE CHLORPHENOXY HERBICIDES MIGHT AUGMENT HUMAN COMMON VIRUSES ASSOCIATED WITH CELL MALIGNIZATION1. "Victims of the Agent Orange/Dioxin in Vietnam", March 2006 edited by Ngueng Thi Bing, President VAVAOD, Le Thi Nham Tuyet Director of Research Center, 03/2006: pages 149-155; FFRP Publishing House, Hanoi, Vietnam.
        • Ilya Tsyrlov: The Membrane Aspects of the Regulation of Monooxygenases. Industrial and Environmental Xenobiotics, Edited by J. Fouts, I. Gut, 01/1978: pages 87-99; Springer, Amsterdam.
        • Ilya Tsyrlov, Nikolay Rivkind, V. Lyakhovich: Metabolism of Polycyclic Hydrocarbons in the Liver of Different Murine Strains in the Course of Chemical Carcinogenesis. Industrial and Environmental Xenobiotics, Edited by Editors: J. Fouts, I. Gut, 01/1978: pages volume 2, pp. 164-184; Springer, Amsterdam.
        • Vyacheslav Lyakhovich, Ilya Tsyrlov, V. Mishin, O. Gromova: Reconstitution of the Microsomal System of Xenobiotic Metabolism. Industrial and Environmental Xenobiotics, Publisher:, Edited by Editors: J. Fouts, I. Gut, 01/1978: pages 1: 99-108; Springer, Amsterdam.
        • Ilya Tsyrlov, Olga Gromova, V. Lyakhovich: Different Phospholipid-Dependent Hydrophobic Zones in Microsomal Membrane Surrounding Cytochrome P-450. Physico-Chemical Basics of Function of Supermolecular Cellular Structures (dedicated to the late Academician A. Belozersky), Edited by A. Belozersky, V. Skulachev, 01/1974: pages volume 2, pp. 120-133; Moscow University Academic Press.
        • Olga Gromova, Ilya Tsyrlov, V. Mishin, N. Zakharova, V. Lyakhovich: Cytochromes P-450 and P-448 Have Different Resistance to the Factors Destabilizing Microsomal Membrane. Physico-Chemical Basics of Function of Supermolecular Cellular Structures (dedicated to the late Academician A. Belozersky),,  Edited by Edited by A. Belozersky, V. Skulachev, pages volume, 01/1974: pages vol. 1:61-67; Moscow University Academic Press.
Journal publications:

PDF list of journal publications.

Patent.

Ilya Tsyrlov and K. Gerasimov: Mode of Production of Long-Acting Drugs Capable of Induction of Mono-Oxygenase System in Human Liver. Ref. No: 145759 3 (Claim # 4105655), Year: 05/1988

Document4.pdf

Conference Proceedings

PDF list of conference proceedings.

List of major coauthors & List of collaborators and fellow scientists from LinkedIn.